New paper on estimating cardiac activation from surface measurements published

Our paper on Inverse estimation of cardiac activation times via gradient-based optimisation is now published online in the International Journal for Numerical Methods in Biomedical Engineering! In this study, we use a PDE-constrained optimal control approach to numerically investigate the identifiability of an initial activation sequence from synthetic observations of the extracellular potential using the bidomain approximation and 2D representations of heart tissue. Our results demonstrate that activation times and duration of several stimuli can be recovered even with high levels of noise, that it is sufficient to sample the observations at the ECG-relevant sampling frequency of 1 kHz, and that spatial resolutions that are coarser than the standard in electrophysiological simulations can be used.graphical_abstract