New paper investigating the effect of injection parameters on drug delivery in the spinal canal published!

pizzichelliOur paper titled Numerical study of intrathecal drug delivery to a permeable spinal cord: effect of catheter position and angle is now published. Intrathecal delivery is a procedure involving the release of therapeutic agents into the cerebrospinal fluid (CSF) through a catheter. It holds promise for treating high-impact central nervous system pathologies, for which systemic administration routes are ineffective. In this study we introduce a numerical model able to simultaneously account for solute transport in the fluid and in the spinal cord. Using a Discontinuous Galerkin method and a three-dimensional patient-specific geometry, we studied the effect of catheter position and angle on local spinal cord drug concentration. Based on our simulations, lateral injection perpendicular to the cord turned out to be more effective than other configurations.