Paper quantifying uncertainties of tracer distribution in the brain published in FBCNS

Our paper on “Uncertainty quantification of parenchymal tracer distribution using random diffusion and convective velocity fields” is now published in Fluids and Barrier of the Central Nervous System. Our main findings are:

  • Uncertainty in diffusion parameters substantially impact the amount of tracer in gray and white matter, and the average tracer concentration in gray and white subregions.
  • Even with an uncertainty in the diffusion coefficient of a factor three, and a resulting fourfold variation in white matter tracer enhancement, discrepancies between simulations of diffusion and experimental data are too large to be attributed to uncertainties in the diffusion coefficient alone.
  • A convective velocity field modelling the glymphatic theory did not increase tracer enhancement in the brain parenchyma compared to pure diffusion. However, when a large-scale directional structure was added to this glymphatic velocity field, tracer inflow increased.
Illustration of velocity field modelling large-scale directionality associated with a glymphatic circulation